منابع مشابه
Inhibiting the inhibitors
It has been known for many years that the immune system can actively respond to (pre)neoplastic cells and prevent oncogenesis (a concept known as cancer immunosurveillance). However, in most cases, antitumor immune responses are inefficient and neoplasms are allowed to establish. Indeed, effector T cells often infiltrate developing malignant lesions and may significantly influence the prognosis...
متن کاملStudent Research Projects Inhibiting Factors from the Students Perspective
Background & Objective: Identifying the research barriers and assess the ability of students to use the university services and facilities is crucial to promote research activities. Present study was carried out to determine the inhibiting factors influencing the student's research projects from the view point of Yasuj University of Medical Sciences students in 2008. Materials & Methods: In thi...
متن کاملMethod for extracting viral hemagglutination-inhibiting antibodies from the nonspecific inhibitors of serum.
Various methods are used to remove nonspecific inhibitors from sera before titering viral hemagglutination-inhibiting antibodies. These methods have several undesirable features; some are tedious and time-consuming, some remove antibody along with nonspecific inhibitors, and different techniques are usually required to remove the nonspecific inhibitors for different viruses. This communication ...
متن کاملInhibiting HIV-1 Entry Discovery of D-Peptide Inhibitors that Target the gp41 Coiled-Coil Pocket
The HIV-1 gp41 protein promotes viral entry by mediating the fusion of viral and cellular membranes. A prominent pocket on the surface of a central trimeric coiled coil within gp41 was previously identified as a potential target for drugs that inhibit HIV-1 entry. We designed a peptide, IQN17, which properly presents this pocket. Utilizing IQN17 and mirror-image phage display, we identified cyc...
متن کاملDiscovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1
A dynamic actin cytoskeleton is necessary for viral entry, intracellular migration, and virion release. For HIV-1 infection, during entry, the virus triggers early actin activity by hijacking chemokine coreceptor signaling, which activates a host dependency factor, cofilin, and its kinase, the LIM domain kinase (LIMK). Although knockdown of human LIM domain kinase 1 (LIMK1) with short hairpin R...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2013
ISSN: 2162-402X
DOI: 10.4161/onci.26535